Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Date

2011

Authors

Morin, Ryan D.
Mendez-Lago, Maria
Mungall, Andrew J.
Goya, Rodrigo
Mungall, Karen
Corbett, Richard
Johnson, Nathalie A.
Severson, Tesa M.
Chiu, Readman
Field, Matthew

Journal Title

Journal ISSN

Volume Title

Publisher

Macmillan Publishers Ltd

Abstract

Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the two most common non-Hodgkin lymphomas (NHLs). Here we sequenced tumour and matched normal DNA from 13 DLBCL cases and one FL case to identify genes with mutations in B-cell NHL. We analysed RNA-seq data from these and another 113 NHLs to identify genes with candidate mutations, and then re-sequenced tumour and matched normal DNA from these cases to confirm 109 genes with multiple somatic mutations. Genes with roles in histone modification were frequent targets of somatic mutation. For example, 32% of DLBCL and 89% of FL cases had somatic mutations in MLL2, which encodes a histone methyltransferase, and 11.4% and 13.4% of DLBCL and FL cases, respectively, had mutations in MEF2B, a calcium-regulated gene that cooperates with CREBBP and EP300 in acetylating histones. Our analysis suggests a previously unappreciated disruption of chromatin biology in lymphomagenesis.

Description

Keywords

Keywords: calcium; DNA; E1A associated p300 protein; histone; histone methyltransferase; RNA; calcium; cytology; enzyme activity; molecular analysis; mutation; protein; tumor; article; biology; cancer genetics; chemical modification; chromatin; follicular lymphoma;

Citation

Source

Nature

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

Restricted until

2037-12-31