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Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

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Date

2001

Authors

Bamber, Dianne
Board, Philip
Coggan, Marjorie
Elder, James
Deakin, Mark
Rajagopal, Ramesh
Fawole, A. Sergei
Strange, Richard
Fryer, Anthony

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.

Description

Keywords

Keywords: Colorectal cancer; Duke's stage; GSTT2; Polymorphism

Citation

URI

http://hdl.handle.net/1885/90730

Collections

ANU Research Publications

Source

Chemico-Biological Interactions

Type

Journal article

Book Title

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