Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer
Date
2001
Authors
Bamber, Dianne
Board, Philip
Coggan, Marjorie
Elder, James
Deakin, Mark
Rajagopal, Ramesh
Fawole, A. Sergei
Strange, Richard
Fryer, Anthony
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.
Description
Keywords
Keywords: Colorectal cancer; Duke's stage; GSTT2; Polymorphism
Citation
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Source
Chemico-Biological Interactions
Type
Journal article