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Construction and evaluation of live attenuated myxoma virus vaccines with targeted virulence gene deletions

Date

Authors

Adams, Mathew

van Leeuwen, Barbara

Kerr, P J

Publisher

Elsevier

Abstract

Three deletion mutant viruses were constructed as potential vaccines against myxomatosis using the naturally attenuated Uriarra strain of myxoma virus. The viruses had the M007 (encodes a secreted γ-interferon receptor homologue), M010 (encodes an epider

Keywords

Keywords: epidermal growth factor; gamma interferon receptor; inhibitor of apoptosis protein; live vaccine; Myxoma virus Ur delta m007 vaccine; Myxoma virus Ur delta m10 m11 vaccine; Myxoma virus Ur triple gene knockout vaccine; unclassified drug; animal cell; anim Myxoma virus; Myxomatosis; Poxvirus; Vaccine

URI

http://hdl.handle.net/1885/50877

Collections

ANU Research Publications

Source

Vaccine

Type

Journal article

DOI

10.1016/j.vaccine.2008.08.036

Restricted until

2037-12-31

Downloads

File

Description

01_Adams_Construction_and_evaluation_of_2008.pdf (2.26 MB)