Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine
Date
2002
Authors
Webster, Diane
Cooney, Michelle
Huang, Zhongjun
Drew, Damian
Ramshaw, Ian
Dry, Ian B
Strugnell, R
Martin, Jenny
Wendler, E
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Microbiology
Abstract
Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.
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Keywords
Keywords: DNA vaccine; measles vaccine; neutralizing antibody; plant extract; virus hemagglutinin; animal experiment; animal model; article; controlled study; eradication therapy; immune response; immunization; measles vaccination; Measles virus; mouse; nonhuman; p
Citation
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Source
Journal of Virology
Type
Journal article
Book Title
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Restricted until
2037-12-31
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