Predicting Cognitive Decline in Healthy Older Adults
Date
2005
Authors
de Jager, Celeste A
Blackwell, Andrew D
Budge, Marc
Sabakian, Barbara J
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Volume Title
Publisher
Lippincott Williams & Wilkins
Abstract
Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a sub-group of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.
Description
Keywords
Keywords: adult; aged; aging; algorithm; Alzheimer disease; article; cognitive defect; controlled study; depression; family history; female; follow up; high risk population; human; intelligence quotient; major clinical study; male; memory; mild cognitive impairment
Citation
Collections
Source
American Journal of Geriatric Psychiatry
Type
Journal article
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Restricted until
2037-12-31