Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice

Date

Authors

Heydet, Deborah

Chen, Lesley X.

Larter, Claire

Inglis, Chrystal

Silverman, Michael A.

Farrell, Geoffrey

Leroux, Michel R.

Publisher

John Wiley & Sons, Inc.

Abstract

Primary cilia are ubiquitous cellular antennae whose dysfunction collectively causes various disorders, including vision and hearing impairment, as well as renal, skeletal, and central nervous system anomalies. One ciliopathy, Alström syndrome, is closel

Keywords

Keywords: alstrom syndrome protein; biological marker; unclassified drug; animal cell; animal experiment; animal model; article; Bardet Biedl syndrome; cell organelle; controlled study; disease marker; female; gene expression; gene mutation; genetic analysis; heari Alms1; Hypothalamus; Obesity; Primary cilium

URI

http://hdl.handle.net/1885/38783

Collections

ANU Research Publications

Source

Developmental Neurobiology

Type

Journal article

DOI

10.1002/dneu.22031

Restricted until

2037-12-31

Downloads

File

Description

01_Heydet_A_truncating_mutation_of_Alms1_2012.pdf (813.19 KB)