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A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice

Date

2012

Authors

Heydet, Deborah
Chen, Lesley X.
Larter, Claire
Inglis, Chrystal
Silverman, Michael A.
Farrell, Geoffrey
Leroux, Michel R.

Journal Title

Journal ISSN

Volume Title

Publisher

John Wiley & Sons, Inc.

Abstract

Primary cilia are ubiquitous cellular antennae whose dysfunction collectively causes various disorders, including vision and hearing impairment, as well as renal, skeletal, and central nervous system anomalies. One ciliopathy, Alström syndrome, is closel

Description

Keywords

Keywords: alstrom syndrome protein; biological marker; unclassified drug; animal cell; animal experiment; animal model; article; Bardet Biedl syndrome; cell organelle; controlled study; disease marker; female; gene expression; gene mutation; genetic analysis; heari Alms1; Hypothalamus; Obesity; Primary cilium

Citation

Source

Developmental Neurobiology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1002/dneu.22031

Restricted until

2037-12-31