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Pharmacogenetic Impact of VKORC1 and CYP2C9 allelic variants on warfarin dose requirements in a hispanic population isolate

Date

Authors

Palacio, L. G.

Falla, D.

Tobon, I.

Mejia, F.

Lewis, J. E.

Martinez, A. F.

Arcos-Burgos, Mauricio

Camargo, Mauricio

Publisher

SAGE Publications

Abstract

Warfarin is the most prescribed oral anticoagulant worldwide. Because of the complexity of warfarin therapy, we attempted to dissect genetic from bioenvironmental factors influencing warfarin dose responses in individuals of a genetic isolate of Hispanic

Keywords

Keywords: warfarin; adult; age; allele; artery thrombosis; article; controlled study; CYP2C9 gene; deep vein thrombosis; environmental factor; female; gene; gene interaction; genetic polymorphism; genetic variability; genotype; genotype environment interaction; His Colombia; CYP2C9; Genetic isolate; Pharmacogenetics; VKORC1; Warfarin

URI

http://hdl.handle.net/1885/79098

Collections

ANU Research Publications

Source

Clinical and Applied Thrombosis/Hemostasis

Type

Journal article

DOI

10.1177/1076029608330472

Restricted until

2037-12-31

Downloads

File

Description

01_Palacio_Pharmacogenetic_Impact_of_2010.pdf (270.12 KB)