Potential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages

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dc.contributor.authorEwart, Gary
dc.contributor.authorNasr, Najla
dc.contributor.authorNaif, Hassan
dc.contributor.authorCox, Graeme
dc.contributor.authorCunningham, Anthony
dc.contributor.authorGage, Peter
dc.date.accessioned2015-12-13T23:06:17Z
dc.date.issued2004
dc.date.updated2015-12-12T08:04:37Z
dc.description.abstractWe report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/1885/85972
dc.publisherAmerican Society for Microbiology
dc.sourceAntimicrobial Agents and Chemotherapy
dc.subjectKeywords: 5 (n,n dimethyl)amiloride; 5 (n,n hexamethylene)amiloride; amiloride derivative; anti human immunodeficiency virus agent; antigen p24; virus DNA; virus RNA; Vpu protein; antiviral activity; article; cell survival; concentration response; HeLa cell; human;
dc.titlePotential New Anti-Human Immunodeficiency Virus Type 1 Compounds Depress Virus Replication in Cultured Human Macrophages
dc.typeJournal article
local.bibliographicCitation.issue6
local.bibliographicCitation.lastpage2330
local.bibliographicCitation.startpage2325
local.contributor.affiliationEwart, Gary, Biotron Ltd
local.contributor.affiliationNasr, Najla, Westmead Millennium Institute
local.contributor.affiliationNaif, Hassan, Westmead Millennium Institute
local.contributor.affiliationCox, Graeme, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCunningham, Anthony, Westmead Millennium Institute
local.contributor.affiliationGage, Peter, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidCox, Graeme, u670017
local.contributor.authoruidGage, Peter, u8404889
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor110804 - Medical Virology
local.identifier.ariespublicationMigratedxPub14675
local.identifier.citationvolume48
local.identifier.doi10.1128/AAC.48.6.2325-2330.2004
local.identifier.scopusID2-s2.0-2542441626
local.type.statusPublished Version

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