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Novel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor

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dc.contributor.authorPeriasamy, Pravin
dc.contributor.authorTan, Jonathan K. H
dc.contributor.authorO'Neill, Helen
dc.date.accessioned2013-09-19T01:24:55Z
dc.date.available2013-09-19T01:24:55Z
dc.date.issued2012-10-25
dc.date.updated2015-12-12T07:42:39Z
dc.description.abstractThe main DC subsets in murine spleen arise from BM-derived precursors. Recently, a novel APC type was described in spleen. To determine if spleen contains the progenitors of this subset, a stromal coculture system was used to assess candidate progenitors for their hematopoietic potential. Here, the progenitor of that subset is identified as a spleen endogenous Lin_c-kit lo hematopoietic progenitor and is most highly enriched among the Lin_c-kit(lo)CD34+ subset. Dendritic-like cells produced in vitro functionally resemble the previously described in vivo equivalent subset with high endocytic capacity and capability for antigen-specific activation of CD8+ T cells but not CD4+ T cells.
dc.description.sponsorshipNHMRC (National Health and Medical Research Council of Australia)en_AU
dc.format7 pages
dc.identifier.issn0741-5400
dc.identifier.issn1938-3673
dc.identifier.urihttp://hdl.handle.net/1885/10501
dc.publisherSociety for Leukocyte Biology
dc.publisherFederation of American Societies for Experimental Biology (FASEB)
dc.relationhttp://purl.org/au-research/grants/nhmrc/585443
dc.rightsThe Deputy Director, Office of Publications, Federation of American Societies for Experimental Biology (FASEB) does not give permission for this article to be deposited in an institutional repository - from email, dated 19/9/13
dc.sourceJournal of Leukocyte Biology 93.1 (2013): 63-9
dc.subjecthematopoiesis
dc.subjectdendritic cells
dc.subjectstroma
dc.titleNovel splenic antigen-presenting cells derive from a Lin(-) c-kit(lo) progenitor
dc.typeJournal article
dcterms.dateAccepted2012-10-07
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpage69
local.bibliographicCitation.startpage63
local.contributor.affiliationPeriasamy, Pravin, ANU, Research School of Biology, Division of Biomedical Sciences
local.contributor.affiliationTan, Jonathan K. H., ANU, Research School of Biology, Division of Biomedical Sciences
local.contributor.affiliationO’Neill, Helen C., ANU, Research School of Biology, Division of Biomedical Sciences
local.contributor.authoruidu8100137en_AU
local.description.notesThis research was funded through a grant. - NHMRCen_AU
local.identifier.absfor169900 - OTHER STUDIES IN HUMAN SOCIETY
local.identifier.ariespublicationf5625xPUB12863
local.identifier.citationvolume93
local.identifier.doi10.1189/jlb.0512260
local.identifier.scopusID2-s2.0-84871955244
local.identifier.thomsonID000313107700009
local.publisher.urlhttp://leukocytebiology.org/Home.aspxen_AU
local.type.statusPublished Versionen_AU

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