The genetic structure of enteric bacteria from Australian mammals

dc.contributor.authorGordon, David
dc.contributor.authorLee, Jane Hyo Jin
dc.date.accessioned2015-12-13T23:20:23Z
dc.date.available2015-12-13T23:20:23Z
dc.date.issued1999
dc.date.updated2015-12-12T09:02:56Z
dc.description.abstractA total of 246 isolates representing five species of the family Enterobacteriaceae, taken from a variety of Australian mammal species, were characterized using multi-locus enzyme electrophoresis. Genome diversity estimates varied significantly among species, with the Klebsiella pneumoniae sample exhibiting the lowest diversity and the Citrobacter freundii sample the highest. Multi-locus linkage disequilibrium estimates revealed that alleles were non-randomly associated in all five species samples, but the magnitude of the estimates differed significantly among species. Escherichia coli had the lowest linkage disequilibrium estimate and Klebisella oxytoca the largest. Molecular analyis of variance was used to determine the extent to which population structure explained the observed genetic variation in a species. Two population levels were defined: the taxonomic family of the host from which the isolate was collected and the geographical locality where the host was collected. The amount of explained variation varied from 0% for K. oxytoca to 22% for K. pneumoniae. Host locality explained a significant amount of the genetic variation in the C. freundii (12%), E. coli (5%), Hafnia alvei (17%) and K. pneumoniae (22%) samples. Host family explained a significant fraction of the variation in E. coli (6%) H. alvei (7%) and K. pneumoniae (20%). Estimates of effective population size for all five species, based on the probability that two randomly chosen isolates will be identical, failed to reveal any relationship between the effective population size and the genetic diversity of a species.
dc.identifier.issn1350-0872
dc.identifier.urihttp://hdl.handle.net/1885/90678
dc.publisherSociety for General Microbiology
dc.sourceMicrobiology (UK)
dc.subjectKeywords: article; Australia; bacterium isolate; Citrobacter freundii; electrophoresis; Enterobacteriaceae; Escherichia coli; gene linkage disequilibrium; gene structure; genetic variability; Hafnia alvei; Klebsiella oxytoca; Klebsiella pneumoniae; mammal; nonhuman Clonality; Enterobacteriaceae; Generic structure; Population structure
dc.titleThe genetic structure of enteric bacteria from Australian mammals
dc.typeJournal article
local.bibliographicCitation.lastpage2682
local.bibliographicCitation.startpage2673
local.contributor.affiliationGordon, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLee, Jane Hyo Jin, College of Physical and Mathematical Sciences, ANU
local.contributor.authoremailu9308141@anu.edu.au
local.contributor.authoruidGordon, David, u9308141
local.contributor.authoruidLee, Jane Hyo Jin, u4241473
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor060501 - Bacteriology
local.identifier.ariespublicationMigratedxPub21110
local.identifier.citationvolume145
local.identifier.scopusID2-s2.0-0032822614
local.identifier.uidSubmittedByMigrated
local.type.statusPublished Version

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