BDNF Exerts Contrasting Effects on Peripheral Myelination of NGF-Dependent and BDNF-Dependent DRG Neurons
Date
2009
Authors
Xiao, Junhua
Wong, Agnes W
Willingham, Melanie M
Kaasinen, Selma
Hendry, Ian
Howitt, Jason
Putz, Ulrich
Barrett, Graham L
Kilpatrick, Trevor J
Murray, Simon S
Journal Title
Journal ISSN
Volume Title
Publisher
Society for Neuroscience
Abstract
Although brain-derived neurotrophic factor (BDNF) has been shown to promote peripheral myelination during development and remy-elination after injury, the precise mechanisms mediating this effect remain unknown. Here, we determine that BDNF promotes myelination of nerve growth factor-dependent neurons, an effect dependent on neuronal expression of the p75 neurotrophin receptor, whereas BDNF inhibits myelination of BDNF-dependent neurons via the full-length TrkB receptor. Thus, BDNF exerts contrasting effects on Schwann cell myelination, depending on the complement of BDNF receptors that are expressed by different subpopulations of dorsal root ganglion neurons. These results demonstrate that BDNF exerts contrasting modulatory roles in peripheral nervous system myelination, and that its mechanism of action is acutely regulated and specifically targeted to neurons.
Description
Keywords
Keywords: brain derived neurotrophic factor; brain derived neurotrophic factor receptor; nerve growth factor; neurotrophin receptor p75; carbazole derivative; enzyme inhibitor; growth factor receptor; indole alkaloid; K 252; myelin associated glycoprotein; myelin b
Citation
Collections
Source
Journal of Neuroscience
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31
Downloads
File
Description