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Novel regulators of RyR Ca(2+) release channels: insight into molecular changes in genetically-linked myopathies

Date

Authors

Dulhunty, Angela

Beard, Nicole

Pouliquin, Pierre

Kimura, Takashi

Publisher

Springer

Abstract

There are many mutations in the ryanodine receptor (RyR) Ca2+ release channel that are implicated in skeletal muscle disorders and cardiac arrhythmias. More than 80 mutations in the skeletal RyR1 have been identified and linked to malignant hyperthermia,

Keywords

Keywords: calcium channel; calcium ion; calsequestrin; receptor subunit; ryanodine receptor; ryanodine receptor 1; ryanodine receptor 2; unclassified drug; article; calcium homeostasis; calcium signaling; calcium transport; gene overexpression; genetic disorder; ge Cardiac muscle; Cardiac RyR-linked myopathies; Inter-domain interactions; Protein-protein interactions; Ryanodine receptor calcium release channels; Skeletal muscle; Skeletal RyR-linked myopathies

URI

http://hdl.handle.net/1885/85122

Collections

ANU Research Publications

Source

Journal of Muscle Research and Cell Motility

Type

Journal article

DOI

10.1007/s10974-006-9086-1

Restricted until

2037-12-31

Downloads

File

Description

01_Dulhunty_Novel_regulators_of_RyR_Ca(2+)_2006.pdf (376.72 KB)

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