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A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations

Date

Authors

Eyers, Fiona

Stambas, John

Boyle, David B

Ramshaw, Ian

Ramsay, Alistair J

Ranasinghe, Charani

Publisher

Elsevier

Abstract

In this study we have firstly compared a range of recombinant DNA poxvirus prime-boost immunisation strategies and shown that combined intramuscular (i.m.) 2× DNA-HIV/intranasal (i.n.) 2× FPV-HIV prime-boost immunisation can generate high-level of HIV-s

Keywords

Keywords: DNA vaccine; Fowlpox virus vector; Gag protein; Human immunodeficiency virus 1 vector; immunoglobulin A; immunoglobulin G; immunoglobulin G1; immunoglobulin G2a; lipofectamine; plasmid DNA; recombinant DNA; unclassified drug; vaccinia virus vector; virus DNA vaccines; Mucosal immunity; Poxvirus vectors; T cell avidity

URI

http://hdl.handle.net/1885/50660

Collections

ANU Research Publications

Source

Vaccine

Type

Journal article

DOI

10.1016/j.vaccine.2011.01.106

Restricted until

2037-12-31

Downloads

File

Description

01_Ranasinghe_A_comparative_analysis_of_2011.pdf (1.05 MB)

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