A comparative analysis of HIV-specific mucosal/systemic T cell immunity and avidity following rDNA/rFPV and poxvirus-poxvirus prime boost immunisations

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Date

2011

Authors

Eyers, Fiona
Stambas, John
Boyle, David B
Ramshaw, Ian
Ramsay, Alistair J
Ranasinghe, Charani

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

In this study we have firstly compared a range of recombinant DNA poxvirus prime-boost immunisation strategies and shown that combined intramuscular (i.m.) 2× DNA-HIV/intranasal (i.n.) 2× FPV-HIV prime-boost immunisation can generate high-level of HIV-s

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Keywords

Keywords: DNA vaccine; Fowlpox virus vector; Gag protein; Human immunodeficiency virus 1 vector; immunoglobulin A; immunoglobulin G; immunoglobulin G1; immunoglobulin G2a; lipofectamine; plasmid DNA; recombinant DNA; unclassified drug; vaccinia virus vector; virus DNA vaccines; Mucosal immunity; Poxvirus vectors; T cell avidity

Citation

URI

http://hdl.handle.net/1885/50660

Collections

ANU Research Publications

Source

Vaccine

Type

Journal article

Book Title

Entity type

Access Statement

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DOI

10.1016/j.vaccine.2011.01.106

Restricted until

2037-12-31

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