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Skeletal muscle ryanodine receptor channels are activated by the fungal metabolite, gliotoxin

Date

Authors

Green, Daniel

Pace, Suzy M

Hurne, Alanna

Waring, Paul

Hart, James

Dulhunty, Angela

Publisher

Springer

Abstract

Interactions between the reactive disulfide fungal metabolite, gliotoxin (GTX), and rabbit skeletal ryanodine receptor (RyR) calcium release channels have been examined. RyRs in terminal cisternae vesicles formed a covalent complex with 100 μM35S-GTX, wh

Keywords

Keywords: dithiothreitol; gliotoxin; ryanodine receptor; animal cell; article; calcium transport; lipid bilayer; nonhuman; oxidation; rabbit; sarcoplasmic reticulum; Animals; Calcium; Dithiothreitol; Gliotoxin; Molecular Structure; Muscle, Skeletal; Rabbits; Ryanod Calcium regulation; Gliotoxin; Ryanodine receptors

URI

http://hdl.handle.net/1885/89001

Collections

ANU Research Publications

Source

Journal of Membrane Biology

Type

Journal article

DOI

10.1007/s002320001070