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Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8 + T Cells with Regime-Dependent Cytokine/Granzyme B Profiles

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Date

2007

Authors

Turner, Stephen
McArthur, Craig
Sutherland, Duncan
Kim, Jee-Hye
Doherty, Peter
Ramshaw, Ian
Ranasinghe, Charani

Journal Title

Journal ISSN

Volume Title

Publisher

American Association of Immunologists

Abstract

The quality of virus-specific CD8+ CTL immune responses generated by mucosal and systemic poxvinis prime-boost vaccines were evaluated in terms of T cell avidity and single-cell analysis of effector gene expression. Intranasal (I.N.) immunization regimes

Description

Keywords

Keywords: cytokine; granzyme B; interleukin 4; live vaccine; messenger RNA; virus vector; adolescent; amino acid sequence; animal cell; animal experiment; article; CD8+ T lymphocyte; controlled study; cytokine production; cytotoxic T lymphocyte; female; gene expres

Citation

URI

http://hdl.handle.net/1885/26293

Collections

ANU Research Publications

Source

Journal of Immunology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31

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