Mucosal HIV-1 Pox Virus Prime-Boost Immunization Induces High-Avidity CD8 + T Cells with Regime-Dependent Cytokine/Granzyme B Profiles

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Turner, Stephen
McArthur, Craig
Sutherland, Duncan
Kim, Jee-Hye
Doherty, Peter
Ramshaw, Ian
Ranasinghe, Charani

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American Association of Immunologists

Abstract

The quality of virus-specific CD8+ CTL immune responses generated by mucosal and systemic poxvinis prime-boost vaccines were evaluated in terms of T cell avidity and single-cell analysis of effector gene expression. Intranasal (I.N.) immunization regimes

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Journal of Immunology

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2037-12-31