Burden of Clostridium difficile infection: Associated hospitalization in a cohort of middle-aged and older adults

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dc.contributor.authorChen, Yingxi
dc.contributor.authorGlass, Katie
dc.contributor.authorLiu, Bette
dc.contributor.authorKorda, Rosemary
dc.contributor.authorRiley, Thomas
dc.contributor.authorKirk, Martyn
dc.date.accessioned2021-05-19T00:54:21Z
dc.date.issued2017
dc.date.updated2020-11-23T10:17:05Z
dc.description.abstractBackground Clostridium difficile is the principal cause of infectious diarrhea in hospitalized patients. The aim of this study was to describe and compare length of stay (LOS), costs, and in-hospital deaths for C difficile infection (CDI) and non-CDI hospitalizations, in a cohort of middle-aged and older Australians. Methods We used survey data from the 45 and Up Study, linked to hospitalization and death data. We calculated the average LOS and costs per hospitalization, and the proportion of in-hospital deaths for CDI and non-CDI hospitalizations. We then compared hospitalizations with CDI as a secondary diagnosis to non-CDI hospitalizations by stratifying hospitalizations based on principal diagnosis and then using generalized linear models to compare LOS and in-hospital costs, and logistic regression for in-hospital deaths, adjusting for age and sex. Results There were 641 CDI hospitalizations during 2006-2012. The average LOS was 17 days; the average cost per hospitalization was AUD 12,704; and in 7.3% of admissions (47 out of 641) the patient died. After adjusting for age and sex, hospitalizations with CDI were associated with longer LOS, higher costs, and a greater proportion of in-hospital deaths compared with hospitalizations with similar principal diagnosis but without CDI. Conclusions CDI places additional burden on the Australian hospital system, with CDI patients having relatively lengthy hospital stays and high costs.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn0196-6553en_AU
dc.identifier.urihttp://hdl.handle.net/1885/233217
dc.language.isoen_AUen_AU
dc.publisherElsevieren_AU
dc.rights© 2017 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevieren_AU
dc.sourceAmerican Journal of Infection Controlen_AU
dc.subjectCDIen_AU
dc.subjectLength of stayen_AU
dc.subjectCosten_AU
dc.subjectIn-hospital deathen_AU
dc.titleBurden of Clostridium difficile infection: Associated hospitalization in a cohort of middle-aged and older adultsen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue5en_AU
local.bibliographicCitation.lastpage511en_AU
local.bibliographicCitation.startpage508en_AU
local.contributor.affiliationChen, Yingxi, College of Health and Medicine, ANUen_AU
local.contributor.affiliationGlass, Katie, College of Health and Medicine, ANUen_AU
local.contributor.affiliationLiu, Bette, University of New South Walesen_AU
local.contributor.affiliationKorda, Rosemary, College of Health and Medicine, ANUen_AU
local.contributor.affiliationRiley, Thomas, University of Western Australiaen_AU
local.contributor.affiliationKirk, Martyn, College of Health and Medicine, ANUen_AU
local.contributor.authoremailu4983108@anu.edu.auen_AU
local.contributor.authoruidChen, Yingxi, u4983108en_AU
local.contributor.authoruidGlass, Katie, u4053649en_AU
local.contributor.authoruidKorda, Rosemary, u4013381en_AU
local.contributor.authoruidKirk, Martyn, u3853379en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor111711 - Health Information Systems (incl. Surveillance)en_AU
local.identifier.absfor111706 - Epidemiologyen_AU
local.identifier.absfor110309 - Infectious Diseasesen_AU
local.identifier.absseo920204 - Evaluation of Health Outcomesen_AU
local.identifier.absseo920105 - Digestive System Disordersen_AU
local.identifier.absseo920109 - Infectious Diseasesen_AU
local.identifier.ariespublicationu4102339xPUB134en_AU
local.identifier.citationvolume45en_AU
local.identifier.doi10.1016/j.ajic.2016.12.006en_AU
local.identifier.scopusID2-s2.0-85009724520
local.identifier.thomsonID000402490100013
local.identifier.uidSubmittedByu4102339en_AU
local.publisher.urlhttp://www.elsevier.com/en_AU
local.type.statusPublished Versionen_AU

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