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Molecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophila

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dc.contributor.authorYounus, Faisal
dc.contributor.authorFraser, Nicholas
dc.contributor.authorCoppin, C.W.
dc.contributor.authorLiu, Jian-Wei
dc.contributor.authorCorrey, Galen
dc.contributor.authorChertemps, Thomas
dc.contributor.authorPandey, Gunjan
dc.contributor.authorMaibeche-Coisne, Martine
dc.contributor.authorJackson, Colin
dc.contributor.authorOakeshott, J.G.
dc.date.accessioned2021-08-16T05:49:29Z
dc.date.available2021-08-16T05:49:29Z
dc.date.issued2017
dc.date.updated2020-11-23T10:50:19Z
dc.description.abstractPrevious electrophysiological and behavioural studies implicate esterase 6 in the processing of the pheromone cis-vaccenyl acetate and various food odorants that affect aggregation and reproductive behaviours. Here we show esterase 6 has relatively high activity against many of the short-mid chain food esters, but negligible activity against cis-vaccenyl acetate. The crystal structure of esterase 6 confirms its substrate-binding site can accommodate many short-mid chain food esters but not cis-vaccenyl acetate. Immunohistochemical assays show esterase 6 is expressed in non-neuronal cells in the third antennal segment that could be accessory or epidermal cells surrounding numerous olfactory sensilla, including basiconics involved in food odorant detection. Esterase 6 is also produced in trichoid sensilla, but not in the same cell types as the cis-vaccenyl acetate binding protein LUSH. Our data support a model in which esterase 6 acts as a direct odorant degrading enzyme for many bioactive food esters, but not cis-vaccenyl acetateen_AU
dc.description.sponsorshipFY was supported by the French-Australian Science and Technology Program (FAST) and a CSIRO OCE Postgraduate scholarship. MM and TC were supported by ANR-12-BSV7-0024-01. CJJ acknowledges beamtime from the Australian Synchrotron (MX2) and a Future Fellowship from the Australian Research Councilen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn2045-2322en_AU
dc.identifier.urihttp://hdl.handle.net/1885/243947
dc.language.isoen_AUen_AU
dc.provenanceThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/en_AU
dc.publisherNature Publishing Groupen_AU
dc.rights© The Author(s) 2017en_AU
dc.rights.licenseCreative Commons Attribution 4.0 International Licenseen_AU
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_AU
dc.sourceScientific Reportsen_AU
dc.titleMolecular basis for the behavioral effects of the odorant degrading enzyme Esterase 6 in Drosophilaen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Accessen_AU
local.bibliographicCitation.lastpage12en_AU
local.bibliographicCitation.startpage1en_AU
local.contributor.affiliationYounus, Faisal, College of Science, ANUen_AU
local.contributor.affiliationFraser, Nicholas, College of Science, ANUen_AU
local.contributor.affiliationCoppin, C.W., CSIRO Land & Water Flagshipen_AU
local.contributor.affiliationLiu, Jian-Wei, CSIROen_AU
local.contributor.affiliationCorrey, Galen, College of Science, ANUen_AU
local.contributor.affiliationChertemps, Thomas, Universite Pierre et Marie Curieen_AU
local.contributor.affiliationPandey, Gunjan, CSIRO (Land & Water Flagship)en_AU
local.contributor.affiliationMaibeche-Coisne, Martine, Universite Pierre et Marie Curieen_AU
local.contributor.affiliationJackson, Colin, College of Science, ANUen_AU
local.contributor.affiliationOakeshott, J.G., CSIRO Land & Water Flagshipen_AU
local.contributor.authoruidYounus, Faisal, u4835789en_AU
local.contributor.authoruidFraser, Nicholas, u5143134en_AU
local.contributor.authoruidCorrey, Galen, u5025097en_AU
local.contributor.authoruidJackson, Colin, u4040768en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor060107 - Enzymesen_AU
local.identifier.absfor100103 - Agricultural Molecular Engineering of Nucleic Acids and Proteinsen_AU
local.identifier.ariespublicationa383154xPUB5742en_AU
local.identifier.citationvolume7en_AU
local.identifier.doi10.1038/srep46188en_AU
local.identifier.scopusID2-s2.0-85017357980
local.identifier.thomsonID000398974000001
local.publisher.urlhttp://www.nature.com/en_AU
local.type.statusPublished Versionen_AU

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