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Enantioselective total syntheses of the alkaloids (−)-rhazinal, (−)-rhazinilam, (−)-leuconolam and (+)- epi -leuconolam

Date

2006

Authors

Banwell, Martin
Beck, Daniel
Willis, Anthony

Journal Title

Journal ISSN

Volume Title

Publisher

ARKAT Foundation

Abstract

The title alkaloids, (-)-1, (-)-2, (-)-4 and (+)-5 respectively, have each been prepared from the enantiomerically enriched (74% ee) tetrahydroindolizine 14 which is itself obtained via an organocatalyzed and enantioselective intramolecular Michael addition reaction of the pyrrole 13 incorporating an N-tethered and β,β-disubstituted acrylaldehyde moiety.

Description

Keywords

(+)-epi-leuconolam, (-)-leuconolam, (-)-rhazinal, (-)-rhazinilam, Enantioselective, Total synthesis

Citation

Source

ARKIVOC

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

Restricted until

2037-12-31