Nitrix oxide activates or inhibits skeletal muscle ryandine receptors depending on its concentration, membrane potential and ligand binding
Date
2000
Authors
Hart, James
Dulhunty, Angela
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Publisher
Springer
Abstract
We show that rabbit skeletal RyR channels in lipid bilayers can be activated or inhibited by NO, in a manner that depends on donor concentration, membrane potential and the presence of channel agonists. 10 μM S-nitroso-N-acetyl-penicillamine (SNAP) incre
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Keywords
Keywords: adenosine triphosphate; calcium channel; dithiothreitol; n acetyl s nitrosopenicillamine; nitric oxide; nitroprusside sodium; peptide; ryanodine receptor; animal tissue; article; calcium transport; channel gating; concentration response; electric potentia Calcium channels; Nitric oxide; Oxidation; Regulatory thiols; Ryanodine receptors; Skeletal Muscle
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Source
Journal of Membrane Biology
Type
Journal article
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Restricted until
2037-12-31
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