Nitrix oxide activates or inhibits skeletal muscle ryandine receptors depending on its concentration, membrane potential and ligand binding

Date

2000

Authors

Hart, James
Dulhunty, Angela

Journal Title

Journal ISSN

Volume Title

Publisher

Springer

Abstract

We show that rabbit skeletal RyR channels in lipid bilayers can be activated or inhibited by NO, in a manner that depends on donor concentration, membrane potential and the presence of channel agonists. 10 μM S-nitroso-N-acetyl-penicillamine (SNAP) incre

Description

Keywords

Keywords: adenosine triphosphate; calcium channel; dithiothreitol; n acetyl s nitrosopenicillamine; nitric oxide; nitroprusside sodium; peptide; ryanodine receptor; animal tissue; article; calcium transport; channel gating; concentration response; electric potentia Calcium channels; Nitric oxide; Oxidation; Regulatory thiols; Ryanodine receptors; Skeletal Muscle

Citation

Source

Journal of Membrane Biology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1007/s002320001022

Restricted until

2037-12-31