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The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro

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Date

2005

Authors

Westman, Belinda J
Beeren, Lisa
Grudzien, Ewa
Stepinski, Janusz
Worch, Remigiusz
Zuberek, Joanna
Jemielity, Jacek
Stolarski, Ryszard
Darzynkiewicz, Edward
Rhoads, Robert E

Journal Title

Journal ISSN

Volume Title

Publisher

Cold Spring Harbor Laboratory Press

Abstract

The eukaryotic initiation factor eIF4E binds the mRNA 5′ cap structure and has a central role during translational initiation. eIF4E and the mechanisms to control its activity have oncogenic properties and thus have become targets for anticancer drug de

Description

Keywords

Keywords: messenger RNA; ribavirin; article; binding affinity; controlled study; correlation analysis; eukaryote; gene function; human; human cell; ligand binding; oncogene; priority journal; RNA translation; Antiviral Agents; Guanosine; Molecular Structure; Protei Antiviral drugs; Cap-dependent translation; eIF4E; Fluorescence quenching; In vitro translation; Translational efficiency

Citation

URI

http://hdl.handle.net/1885/52660

Collections

ANU Research Publications

Source

RNA

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1261/rna.2132505

Restricted until

2037-12-31

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01_Westman_The_antiviral_drug_ribavirin_2005.pdf (326.4 KB)

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