Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Brain plasticity, memory and neurological disorders: an epigenetic perspective

Simple item page
dc.contributor.authorLockett, Gabrielle
dc.contributor.authorWilkes (previously Baglow), Fiona
dc.contributor.authorMaleszka, Ryszard
dc.date.accessioned2015-12-10T23:06:00Z
dc.date.issued2010
dc.date.updated2016-02-24T12:08:01Z
dc.description.abstractEpigenomic settings control gene regulation in both developing and postmitotic tissue, whereas abnormal regulation of epigenomic settings has been implicated in many developmental and neurological disorders. Evidence is emerging for the roles of epigenetic mechanisms in the mature nervous system, in the dynamic processes of learning and memory. The discovery of the involvement of DNA methylation and histone acetylation and methylation in neuronal processing provides a possible answer to the long-standing riddle of how memories persist in a biological system whose cellular composition is in a constant state of flux and renewal. This mini review focuses on present research in DNA methylation and histone posttranslational modifications in learning and memory, age-related cognitive decline, and related pathological disorders.
dc.identifier.issn0959-4965
dc.identifier.urihttp://hdl.handle.net/1885/62593
dc.publisherLippincott Williams & Wilkins
dc.sourceNeuroReport
dc.subjectKeywords: histone; acetylation; Alzheimer disease; amyotrophic lateral sclerosis; cognitive defect; DNA methylation; epigenetics; fragile X syndrome; Friedreich ataxia; genetic disorder; human; Huntington chorea; learning; memory; nerve cell plasticity; nervous sys ageing; DNA methylation; histone modification; honey bee; learning; memory; neurodegeneration; neurological disorders
dc.titleBrain plasticity, memory and neurological disorders: an epigenetic perspective
dc.typeJournal article
local.bibliographicCitation.issue14
local.bibliographicCitation.lastpage913
local.bibliographicCitation.startpage909
local.contributor.affiliationLockett, Gabrielle, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWilkes (previously Baglow), Fiona, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMaleszka, Ryszard, College of Medicine, Biology and Environment, ANU
local.contributor.authoruidLockett, Gabrielle, u4390353
local.contributor.authoruidWilkes (previously Baglow), Fiona, u4314249
local.contributor.authoruidMaleszka, Ryszard, u8709305
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor060410 - Neurogenetics
local.identifier.absfor060404 - Epigenetics (incl. Genome Methylation and Epigenomics)
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.absseo970111 - Expanding Knowledge in the Medical and Health Sciences
local.identifier.ariespublicationu9511635xPUB714
local.identifier.citationvolume21
local.identifier.doi10.1097/WNR.0b013e32833e9288
local.identifier.scopusID2-s2.0-77956398534
local.type.statusPublished Version

Downloads

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
01_Lockett_Brain_plasticity,_memory_and_2010.pdf
Size:
139.78 KB
Format:
Adobe Portable Document Format
Download

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS