The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil

Watson, Clare A.; Vine, Kara L.; Locke, Julie M.; Bezos, Anna; Ranson, Marie; Parish, Christopher

The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil

Date

2013

Authors

Watson, Clare A.

Vine, Kara L.

Locke, Julie M.

Bezos, Anna

Ranson, Marie

Parish, Christopher

Publisher

Lippincott Williams & Wilkins Ltd.

Abstract

Sulfated β-cyclodextrins (S-β-CDs) are useful excipients for improving the solubility of drugs. One such formulation incorporating 5-fluorouracil (5-FU), termed FD(S), showed improved efficacy over 5-FU alone in orthotopic carcinoma xenograft models. S-