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The antiangiogenic properties of sulfated β-cyclodextrins in anticancer formulations incorporating 5-fluorouracil

Date

Authors

Watson, Clare A.

Vine, Kara L.

Locke, Julie M.

Bezos, Anna

Ranson, Marie

Parish, Christopher

Publisher

Lippincott Williams & Wilkins Ltd.

Abstract

Sulfated β-cyclodextrins (S-β-CDs) are useful excipients for improving the solubility of drugs. One such formulation incorporating 5-fluorouracil (5-FU), termed FD(S), showed improved efficacy over 5-FU alone in orthotopic carcinoma xenograft models. S-

Keywords

Keywords: beta cyclodextrin; fluorouracil; angiogenesis; animal experiment; animal model; animal tissue; antiangiogenic activity; antineoplastic activity; article; cell kinetics; cell migration; cell proliferation; chick embryo; chorioallantois; controlled study; d ß-cyclodextrin; 5-fluorouracil; angiogenesis; cancer; endothelial cells; heparin

URI

http://hdl.handle.net/1885/73258

Collections

ANU Research Publications

Source

Anti-Cancer Drugs

Type

Journal article

DOI

10.1097/CAD.0b013e3283626fdd

Restricted until

2037-12-31

Downloads

File

Description

01_Watson_The_antiangiogenic_properties_2013.pdf (604.4 KB)