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Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide

Date

2007

Authors

Xu, Y
Chen, A
Fry, S
Barrow, Russell
Marshall, R L
Mukkur, T K S

Journal Title

Journal ISSN

Volume Title

Publisher

Elsevier

Abstract

Gavage of mice, immunised with an inactivated S. typhimurium vaccine, with Andrographis paniculata extract [APE] or andrographolide [AND] resulted in an enhancement of Salmonella-specific antibody response and induction of cell-mediated response against salmonellosis. Mice were vaccinated with either one or two doses of killed S. typhimurium vaccine and fed two different quantities of APE or AND, for 14 days in mice immunised with one dose of the vaccine, and for 28 days in mice immunised with two doses of vaccine, respectively. Both APE and AND were found to enhance IgG antibody levels against S. typhimurium, the enhancement being statistically significant in mice receiving two doses of the vaccine. Splenocyte cultures, prepared from mice immunised with the killed Salmonella vaccine and treated with APE or AND, showed a remarkable increase in the production IFN-γ following stimulation with the bacterial lysate, indicating an induction of Salmonella-specific cell-mediated response/immune response.

Description

Keywords

Keywords: Andrographis paniculata extract; andrographolide; bacterium lysate; gamma interferon; immunoglobulin G antibody; inactivated vaccine; salmonellosis vaccine; Andrographis paniculata; animal experiment; animal model; antibody response; article; cell culture Andrographis paniculata; Andrographolide; Antibody response; Cell-mediated immunity; Immunomodulatory

Citation

Source

International Immunopharmacology

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1016/j.intimp.2006.12.008

Restricted until

2037-12-31