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Identification and characterization of an unusual metallo-β-lactamase from Serratia proteamaculans

Date

Authors

Vella, Peter

Miraula, Manfredi

Phelan, Emer

Leung, Eleanor W W

Ely, Fernanda

Ollis, David

McGeary, Ross Peter

Schenk, Gerhard

Mitic, Natasa

Publisher

Springer

Abstract

Metallo-β-lactamases (MBLs) are a family of metalloenzymes that are capable of hydrolyzing β-lactam antibiotics and are an important means by which bacterial pathogens use to inactivate antibiotics. A database search of the available amino acid sequence

Keywords

Keywords: ampicillin; biapenem; cefalotin; cefmetazole; cefoxitin; ceftazidime; cefuroxime; cephalosporin; imipenem; latamoxef; meropenem; metallo beta lactamase; penicillin G; piperacillin; amino acid sequence; amino acid substitution; antibiotic resistance; artic Antibiotics resistance; Binuclear metallohydrolases; Infectious disease; Metallo-ß-lactamases; Sequence homology

URI

http://hdl.handle.net/1885/62409

Collections

ANU Research Publications

Source

Journal of Biological Inorganic Chemistry

Type

Journal article

DOI

10.1007/s00775-013-1035-z

Restricted until

2037-12-31

Downloads

File

Description

01_Vella_Identification_and_2013.pdf (387.93 KB)