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Solution Structure of mu-Conotoxin PIIIA, a Preferential Inhibitor of Persistent Tetrodotoxin-sensitive Sodium Channels

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Date

2002

Authors

Nielsen, Katherine
Watson, Michael
Adams, David
Hammarstrom, Anna
Gage, Peter
Hill, James O
Craik, David J
Thomas, Linda
Adams, Denise
Alewood, Paul F

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

μ-Conotoxins are peptide inhibitors of voltage-sensitive sodium channels (VSSCs). Synthetic forms of μ-conotoxins PIIIA and PIIIA-(2-22) were found to inhibit tetrodotoxin (TTX)-sensitive VSSC current but had little effect on TTX-resistant VSSC current

Description

Keywords

Keywords: Assays; Brain; Conformations; Electric potential; Isomerization; Muscle; Neurology; Nuclear magnetic resonance; Sodium; Radioligands; Biochemistry; conotoxin; hydroxyproline; inhibitor protein; mu conotoxin GIIIA; mu conotoxin PIIIA; radioligand; sodium c

Citation

URI

http://hdl.handle.net/1885/72976

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1074/jbc.M201611200

Restricted until

2037-12-31

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