Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors

Barker, David; Lin, Diana S-H; Carland, Jane E; Chu, Cindy P-Y; Chebib, Mary; Brimble, Margaret A; Savage, G Paul; McLeod, Malcolm

Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors

Date

2005

Authors

Barker, David

Lin, Diana S-H

Carland, Jane E

Chu, Cindy P-Y

Chebib, Mary

Brimble, Margaret A

Savage, G Paul

McLeod, Malcolm

Publisher

Pergamon-Elsevier Ltd

Abstract

Bicyclic analogues of methyllycaconitine (MLA), such as 12, have been synthesised that incorporate the C1-OMe substituent present in the natural product. Electrophysiology experiments using Xenopus oocytes expressing nicotinic acetylcholine receptors (nAChRs) were conducted on these analogues and a related tricyclic analogue 2. The most potent compound, 2, was an antagonist at all receptors studied but displayed different antagonist effects at each receptor subtype. This study more clearly defines the biological effects of MLA analogues at nAChRs and demonstrates that these analogues are not selective ligands for the α7 nAChR subtype.