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Total Synthesis of (±)-Vibsanin E

Date

2009

Authors

Schwartz, Brett
Denton, Justin R
Davies, Huw ML
Williams, Craig

Journal Title

Journal ISSN

Volume Title

Publisher

CSIRO Publishing

Abstract

Vibsanin E (1), a structurally rare complex diterpene, consisting of a compact 3-oxatricyclo[6.3.2.05,10] tridecane core and an unprecedented 3,3-dimethylacroyl enol ester functional group, formulate a considerable synthetic challenge. Williams and Davies failed to independently synthesize this nemesis, however, a 'two heads are better than one' approach delivered the first total synthesis of the molecule, since its diamond aniversary isolation.

Description

Keywords

Keywords: Diterpenes; Enol esters; Total synthesis; Williams; Esters; Olefins; Functional groups

Citation

Source

Australian Journal of Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1071/CH09267

Restricted until

2037-12-31