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Inhibition of Peptidylglycine α-Amidating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals

Date

2004

Authors

Barratt, Brendon
Easton, Christopher
Henry, David
Li, Iris
Radom, Leo
Simpson, Jamie S

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Peptidylglycine α-amidating monooxygenase catalyzes the biosynthesis of peptide hormones through radical cleavage of the C-terminal glycine residues of the corresponding prohormones. We have correlated ab initio calculations of radical stabilization ener

Description

Keywords

Keywords: Biosynthesis; Catalysis; Free radicals; Hormones; Free radical brominations; Monooxygenase; Radical stabilization energy; Enzymes; alpha amidating enzyme; glycine derivative; glycolic acid; hormone precursor; peptide hormone; radical; unspecific monooxyge

Citation

Source

Journal of the American Chemical Society

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ja046204n

Restricted until