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Inhibition of Peptidylglycine α-Amidating Monooxygenase by Exploitation of Factors Affecting the Stability and Ease of Formation of Glycyl Radicals

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Date

2004

Authors

Barratt, Brendon
Easton, Christopher
Henry, David
Li, Iris
Radom, Leo
Simpson, Jamie S

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

Peptidylglycine α-amidating monooxygenase catalyzes the biosynthesis of peptide hormones through radical cleavage of the C-terminal glycine residues of the corresponding prohormones. We have correlated ab initio calculations of radical stabilization ener

Description

Keywords

Keywords: Biosynthesis; Catalysis; Free radicals; Hormones; Free radical brominations; Monooxygenase; Radical stabilization energy; Enzymes; alpha amidating enzyme; glycine derivative; glycolic acid; hormone precursor; peptide hormone; radical; unspecific monooxyge

Citation

URI

http://hdl.handle.net/1885/77654

Collections

ANU Research Publications

Source

Journal of the American Chemical Society

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ja046204n

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