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The significance of regional metastasis location in head and neck cutaneous squamous cell carcinoma

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dc.contributor.authorMooney, Craig
dc.contributor.authorClark, Jonathan R.
dc.contributor.authorShannon, Kerwin
dc.contributor.authorPalme, Carsten
dc.contributor.authorEbrahimi, Ardalan
dc.contributor.authorGao, Kan
dc.contributor.authorCh'ng, Sydney
dc.contributor.authorElliott, Michael
dc.contributor.authorGupta, Ruta
dc.contributor.authorLow, Tsu-Hui (Hubert)
dc.date.accessioned2023-11-28T00:21:45Z
dc.date.issued2021
dc.date.updated2022-08-21T08:16:29Z
dc.description.abstractBackground: Regional metastasis of head and neck cutaneous squamous cell carcinoma (HNcSCC) can be seen in either parotid and/or cervical lymph nodes. The aim of this study was to assess whether there was a difference in prognosis between parotid and cervical nodal metastases. Methods: Patients with regional metastasis from HNcSCC were identified from an institutional database. Disease-specific (DSS) and overall survival (OS) were calculated using the Kaplan–Meier method and Cox proportional hazards models. Results: Five hundred and thirty-five patients were identified with median follow-up of 26.4 months (3–255 months). Two hundred and thirty-five patients had parotid metastasis, 96 patients had neck metastasis, and 204 patients had both. On multivariable analysis, any regional metastasis to the neck when compared to parotid alone conferred worse DSS (HR 1.8, p = 0.007) and OS (HR 1.3, p = 0.024). Conclusion: Regional metastasis of HNcSCC to the neck confers worse outcomes compared to metastasis to the parotid alone.en_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1043-3074en_AU
dc.identifier.urihttp://hdl.handle.net/1885/307468
dc.language.isoen_AUen_AU
dc.publisherJohn Wiley & Sons Inc.en_AU
dc.rights© 2021 Wiley Periodicals LLCen_AU
dc.sourceHead and Necken_AU
dc.subjecthead and neck canceren_AU
dc.subjectmetastasisen_AU
dc.subjectparotid canceren_AU
dc.subjectskin canceren_AU
dc.subjectsquamous cell canceren_AU
dc.titleThe significance of regional metastasis location in head and neck cutaneous squamous cell carcinomaen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue9en_AU
local.bibliographicCitation.lastpage2711en_AU
local.bibliographicCitation.startpage2705en_AU
local.contributor.affiliationMooney, Craig, Sydney Head and Neck Cancer Instituteen_AU
local.contributor.affiliationClark , Jonathan R. , Department of Head and Neck Surgery,Sydney Head and Neck Cancer Instituteen_AU
local.contributor.affiliationShannon, Kerwin, Sydney Head and Neck Cancer Instituteen_AU
local.contributor.affiliationPalme, Carsten, Sydney Head and Neck Cancer Instituteen_AU
local.contributor.affiliationEbrahimi, Ardalan, College of Health and Medicine, ANUen_AU
local.contributor.affiliationGao, Kan, Sydney Head and Neck Cancer Instituteen_AU
local.contributor.affiliationCh'ng, Sydney, University of Sydneyen_AU
local.contributor.affiliationElliott, Michael, University of Sydneyen_AU
local.contributor.affiliationGupta, Ruta, University of Sydneyen_AU
local.contributor.affiliationLow, Tsu-Hui (Hubert), University of Sydneyen_AU
local.contributor.authoruidEbrahimi, Ardalan, u6883680en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor321111 - Solid tumoursen_AU
local.identifier.ariespublicationa383154xPUB19565en_AU
local.identifier.citationvolume43en_AU
local.identifier.doi10.1002/hed.26744en_AU
local.identifier.scopusID2-s2.0-85106249239
local.identifier.thomsonIDWOS:000652640800001
local.publisher.urlhttps://www.wiley.com/en-gben_AU
local.type.statusPublished Versionen_AU

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