Development of two distinct dendritic-like APCs in the context of splenic stroma

Periasamy, Pravin; Petvises, Sawang; O'Neill, Helen

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Development of two distinct dendritic-like APCs in the context of splenic stroma

Date

2013

Authors

Periasamy, Pravin

Petvises, Sawang

O'Neill, Helen

Publisher

Frontiers Research Foundation

Abstract

Murine splenic stroma has been found to provide an in vitro niche for hematopoiesis of dendritic-like APC. Two distinct cell types have been characterized. The novel "L-DC" subset has cross-presenting capacity, leading to activation of CD8+ T cells, but n