Investigation into the prevalence of a novel dendritic-like cell subset in vivo

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dc.contributor.authorGriffiths, Kristin Lisa
dc.contributor.authorTan, Jonathan Kah Huat
dc.contributor.authorO’Neill, Helen Christine
dc.date.accessioned2014-02-24T01:05:23Z
dc.date.available2014-02-24T01:05:23Z
dc.date.issued2013-12
dc.date.updated2015-12-11T09:52:13Z
dc.description.abstractA novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8+ T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct subset also present in bone marrow. The prevalence of the subset is low; ~6% of all dendritic and myeloid cells in the spleen and ~5% in blood. However, they are a distinct cell type on the basis of marker expression, and endocytic and T-cell stimulatory capacity. Attempts to identify an enriched population of these cells in mutant mouse strains with reported increases in myelopoiesis showed either a lack of L-DC or an altered phenotype reflective of the phenotype of the mouse strain.
dc.format11 pages
dc.identifier.issn1582-1838
dc.identifier.urihttp://hdl.handle.net/1885/11414
dc.publisherWiley Open Access
dc.relationhttp://purl.org/au-research/grants/nhmrc/585443
dc.rights© 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.sourceJournal of Cellular and Molecular Medicine 17.12 (2013): 1608-1618
dc.subjectdendritic cells
dc.subjectcross-presentation
dc.subjectspleen
dc.subjectbone marrow
dc.titleInvestigation into the prevalence of a novel dendritic-like cell subset in vivo
dc.typeJournal article
dcterms.dateAccepted2013-10-02
local.bibliographicCitation.issue12
local.bibliographicCitation.lastpage1618
local.bibliographicCitation.startpage1608
local.contributor.affiliationGriffiths, Kristin Lisa, Research School of Biology, The Australian National University
local.contributor.affiliationTan, Jonathan Kah Huat, Research School of Biology, The Australian National University
local.contributor.affiliationO’Neill, Helen Christine, Research School of Biology, The Australian National University
local.contributor.authoremailhelen.oneill@anu.edu.auen_AU
local.contributor.authoruidu8100137en_AU
local.identifier.absfor110704 - Cellular Immunology
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.absseo920108 - Immune System and Allergy
local.identifier.ariespublicationf5625xPUB6658
local.identifier.citationvolume17
local.identifier.doi10.1111/jcmm.12174
local.identifier.scopusID2-s2.0-84891152918
local.identifier.thomsonID000328817900010
local.identifier.uidSubmittedByu8100137en_AU
local.publisher.urlhttp://www.wileyopenaccess.com/view/index.htmlen_AU
local.type.statusPublished Versionen_AU

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