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The Expanding Class 2 CRISPR Toolbox: Diversity, licability, and Targeting Drawbacks

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dc.contributor.authorHajizadeh Dastjerdi, Arash
dc.contributor.authorNewman, Anthony
dc.contributor.authorBurgio, Gaetan
dc.date.accessioned2021-07-08T23:02:35Z
dc.date.available2021-07-08T23:02:35Z
dc.date.issued2019-08-05
dc.description.abstractThe class 2 clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, one of the prokaryotic adaptive immune systems, has sparked a lot of attention for its use as a gene editing tool. Currently, type II, V, and VI effector modules of this class have been characterized and extensively tested for nucleic acid editing, imaging, and disease diagnostics. Due to the unique composition of their nuclease catalytic center, the effector modules substantially vary in their function and possible biotechnology applications. In this review, we discuss the structural and functional diversity in class 2 CRISPR effectors, and debate their suitability for nucleic acid targeting and their shortcomings as gene editing tools.en_AU
dc.description.sponsorshipDr. Burgio’s research program is supported by the National Health and Medical Research Council of Australia (APP1143008), the Australian Research Council (DP180101494), and the National Collaborative Research Infrastructure Strategy (NCRIS) via the Australian Phenomics Network. Arash Hajizadeh Dastjerdi is supported by a JCSMR postgraduate scholarship, and Anthony Newman is supported by a Research Training Program domestic scholarship.en_AU
dc.identifier.citationHajizadeh Dastjerdi, A., Newman, A. & Burgio, G. The Expanding Class 2 CRISPR Toolbox: Diversity, Applicability, and Targeting Drawbacks. BioDrugs 33, 503–513 (2019). https://doi.org/10.1007/s40259-019-00369-yen_AU
dc.identifier.issn1173-8804en_AU
dc.identifier.urihttp://hdl.handle.net/1885/238631
dc.provenancehttps://v2.sherpa.ac.uk/id/publication/18253..."Author accepted manuscript can be made open access on institutional repository after 12 month embargo" from SHERPA/RoMEO site (as at 9.7.2021).
dc.publisherAdis International Ltd.en_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/1143008en_AU
dc.relationhttp://purl.org/au-research/grants/arc/DP180101494en_AU
dc.rights© 2019 Springer Nature Switzerland AGen_AU
dc.sourceBioDrugsen_AU
dc.titleThe Expanding Class 2 CRISPR Toolbox: Diversity, licability, and Targeting Drawbacksen_AU
dc.typeJournal articleen_AU
dcterms.accessRightsOpen Access
local.bibliographicCitation.issue5en_AU
local.bibliographicCitation.lastpage513en_AU
local.bibliographicCitation.startpage503en_AU
local.contributor.affiliationHajizadeh Dastjerdi, Arash, College of Health and Medicine, ANUen_AU
local.contributor.affiliationNewman, Anthony, College of Health and Medicine, ANUen_AU
local.contributor.affiliationBurgio, Gaetan, College of Health and Medicine, ANUen_AU
local.contributor.authoruidBurgio, Gaetan, u5727247en_AU
local.description.notesAdded manually as didn't import from ARIESen_AU
local.identifier.ariespublicationu5786633xPUB1021en_AU
local.identifier.citationvolume33en_AU
local.identifier.doi10.1007/s40259-019-00369-yen_AU
local.publisher.urlhttps://link.springer.com/en_AU
local.type.statusAccepted versionen_AU

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