Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Modelling linkage and association, with evaluation of common sampling schemes

Simple item page
dc.contributor.authorWicks, J
dc.contributor.authorWilson, Susan
dc.date.accessioned2015-12-13T23:41:31Z
dc.date.available2015-12-13T23:41:31Z
dc.date.issued1999
dc.date.updated2015-12-12T09:32:50Z
dc.description.abstractThe probability model of parental transmission (of a multiallelic marker) to affected offspring has been reparameterized in such a way as to distinguish the recombination fraction parameter from the association parameters. The advantage of this reparameterization is that statistical tests can be developed which disentangle linkage and association. It is shown that these tests perform well compared with a standard approach that is commonly used. Further, the simulated data (Problem 2) enable a comparison to be made of the performance of these tests under different family sampling schemes.
dc.identifier.issn0741-0395
dc.identifier.urihttp://hdl.handle.net/1885/94942
dc.publisherWiley-Liss Inc
dc.sourceGenetic Epidemiology
dc.subjectKeywords: child parent relation; conference paper; genetic association; genetic linkage; intermethod comparison; mathematical model; maximum likelihood method; probability; simulation; Family; Humans; Likelihood Functions; Linkage (Genetics); Linkage Disequilibrium Ascertainment sampling schemes; Likelihood ratio tests; Transmission/disequilibrium test
dc.titleModelling linkage and association, with evaluation of common sampling schemes
dc.typeJournal article
local.bibliographicCitation.issue1
local.bibliographicCitation.lastpageS760
local.bibliographicCitation.startpageS755
local.contributor.affiliationWicks, J, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWilson, Susan, College of Physical and Mathematical Sciences, ANU
local.contributor.authoruidWicks, J, u9205966
local.contributor.authoruidWilson, Susan, u7401449
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.absfor010405 - Statistical Theory
local.identifier.ariespublicationMigratedxPub24655
local.identifier.citationvolume17
local.identifier.scopusID2-s2.0-0032735662
local.type.statusPublished Version

Downloads

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS

abcd