Synthesis of [123l] iodine labelled imidazo [1,2-b] pyridazines as potential probes for the study of peripheral benzodiazepine receptors using SPECT

Abstract

The pyridazines 3-acetamidomethyl-6-chloro-2-(4′-iodophenyl) imidazo[1,2-b]pyridazine 1 (IC50 = 1.6 nM) and 3-benzanfidomethyl-6- iodo-2-(4′-t-butylphenyl)imidazo[1,2-b] pyridazine 2 (IC50 = 4.2 nM), are high affinity and selective ligands for the Per Show more