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A Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cells

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dc.contributor.authorYu, Di
dc.contributor.authorYe, Lilin
dc.date.accessioned2022-11-30T00:00:49Z
dc.date.issued2018
dc.date.updated2021-11-28T07:29:59Z
dc.description.abstractCD8+ T cells differentiate into multiple effector and memory subsets to carry out immune clearance of infected and cancerous cells and provide long-term protection. Recent research identified a CXCR5+Tcf1+Tim-3− subset that localizes in, or proximal to, B cell follicles in secondary lymphoid organs of mice, non-human primates, and humans, hereby termed follicular cytotoxic T (TFC) cells. With remarkable similarity to follicular helper T (TFH) cells, TFC differentiation is dependent on transcription factors E2A, Bcl6, and Tcf1, but inhibited by other regulators, including Blimp1, Id2, and Id3. This review summarizes the phenotype, function, and differentiation of this new subset. Owing to its follicular location and self-renewal capability, we propose immunotherapeutic strategies to target TFC cells to potentially treat certain cancers and chronic infections such as HIV-1.en_AU
dc.description.sponsorshipThis work was supported by Australian National Health and Medical Research Council (GNT1147709 to D.Y.), the National Key Research and Development Program of China (2017YFC0909003 to D.Y.), the amfAR Research Consortium on HIV Eradication (109327-59-RGRL to D. Y), the Shandong Provincial Natural Science Foundation (ZR2016YL013 to D.Y.) and Priority Research Program of Shandong Academy of Sciences (D.Y.). D.Y. is supported by the Bellberry-Viertel Senior Medical Research Fellowship and intramural funds from The Australian National University, Shandong Academy of Sciences and Renji Hospitaen_AU
dc.format.mimetypeapplication/pdfen_AU
dc.identifier.issn1471-4906en_AU
dc.identifier.urihttp://hdl.handle.net/1885/281395
dc.language.isoen_AUen_AU
dc.publisherElsevieren_AU
dc.relationhttp://purl.org/au-research/grants/nhmrc/GNT1147709en_AU
dc.rights© 2018 Elsevier Ltd.en_AU
dc.sourceTrends in Immunologyen_AU
dc.titleA Portrait of CXCR5+ Follicular Cytotoxic CD8+ T cellsen_AU
dc.typeJournal articleen_AU
local.bibliographicCitation.issue12en_AU
local.bibliographicCitation.lastpage979en_AU
local.bibliographicCitation.startpage965en_AU
local.contributor.affiliationYu, Di, College of Health and Medicine, ANUen_AU
local.contributor.affiliationYe, Lilin, Third Military Medical Universityen_AU
local.contributor.authoruidYu, Di, u2506956en_AU
local.description.embargo2099-12-31
local.description.notesImported from ARIESen_AU
local.identifier.absfor320404 - Cellular immunologyen_AU
local.identifier.absseo200105 - Treatment of human diseases and conditionsen_AU
local.identifier.absseo200104 - Prevention of human diseases and conditionsen_AU
local.identifier.ariespublicationu3102795xPUB380en_AU
local.identifier.citationvolume39en_AU
local.identifier.doi10.1016/j.it.2018.10.002en_AU
local.identifier.scopusID2-s2.0-85055449628
local.publisher.urlhttps://www.elsevier.com/en-auen_AU
local.type.statusPublished Versionen_AU

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