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Formal total synthesis of triptolide

Date

Authors

Miller, Natalie

Willis, Anthony

Sherburn, Michael

Publisher

Royal Society of Chemistry

Abstract

A new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels-Alder reactions and a new deoxygenative aromatisation process.

Keywords

Keywords: natural product; triptolide; aromatization; article; deoxygenation; Diels Alder reaction; drug synthesis; Diterpenes; Epoxy Compounds; Phenanthrenes; Stereoisomerism

URI

http://hdl.handle.net/1885/50128

Collections

ANU Research Publications

Source

Chemical Communications

Type

Journal article

DOI

10.1039/b718754h

Restricted until

2037-12-31

Downloads

File

Description

01_Miller_Formal_total_synthesis_of_2008.pdf (664.69 KB)

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