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Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

Date

Authors

Sun, Ramon

Fadia, Mitali

Board, Philip

Blackburn, Anneke

Dahlstrom, Jane

Parish, Christopher

Publisher

Springer

Abstract

The glycolytic phenotype is a widespread phenomenon in solid cancer forms, including breast cancer. Dichloroacetate (DCA) has recently been proposed as a novel and relatively non-toxic anti-cancer agent that can reverse the glycolytic phenotype in cancer

Keywords

Keywords: caspase 3; caspase 7; dichloroacetic acid; glutathione s transferase z1; glutathione transferase; unclassified drug; animal cell; animal experiment; animal model; animal tissue; apoptosis; article; breast adenocarcinoma; breast cancer; cancer cell; cancer Animal model; Breast cancer; Dichloroacetate; Glycolysis; Metastasis

URI

http://hdl.handle.net/1885/49627

Collections

ANU Research Publications

Source

Breast Cancer Research and Treatment

Type

Journal article

DOI

10.1007/s10549-009-0435-9

Restricted until

2037-12-31

Downloads

File

Description

01_Sun_Reversal_of_the_glycolytic_2009.pdf (459 KB)