Biological evaluation of ent -narciclasine, ent -lycoricidine and certain enantiomerically-related congeners

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dc.contributor.authorMatveenko, Maria
dc.contributor.authorBanwell, Martin
dc.contributor.authorJoffe, Max
dc.contributor.authorWan, Soosan
dc.contributor.authorFantino, Emmanuelle
dc.date.accessioned2015-12-10T22:30:18Z
dc.date.issued2009
dc.date.updated2016-02-24T10:23:01Z
dc.description.abstractThe non-natural enantiomeric forms of narciclasine and lycoricidine ((-)-1 and (-)-2, respectively), as well as congeners 3-6 are available through chemoenzymatic synthesis. Accordingly, they have now been tested for their cytotoxic effects in a 13-member human cancer cell-line panel and found to be only weakly active. In contrast, an authentic sample of the natural enantiomeric form of narciclasine ((+)-1) was found to be highly active in the same screens.
dc.identifier.issn1612-1872
dc.identifier.urihttp://hdl.handle.net/1885/55037
dc.publisherWiley-VCH Verlag GMBH
dc.sourceChemistry & Biodiversity
dc.subjectKeywords: antineoplastic agent; lycoricidine; narciclasine; unclassified drug; antineoplastic activity; article; cancer cell culture; drug cytotoxicity; drug screening; drug synthesis; enantiomer; female; human; human cell; male; Amaryllidaceae Alkaloids; Antineopl
dc.titleBiological evaluation of ent -narciclasine, ent -lycoricidine and certain enantiomerically-related congeners
dc.typeJournal article
local.bibliographicCitation.issue5
local.bibliographicCitation.lastpage691
local.bibliographicCitation.startpage685
local.contributor.affiliationMatveenko, Maria, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationBanwell, Martin, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationJoffe, Max, Cytopia Pty Ltd
local.contributor.affiliationWan, Soosan, Cytopia Pty Ltd
local.contributor.affiliationFantino, Emmanuelle, Cytopia Pty Ltd
local.contributor.authoruidMatveenko, Maria, u4195285
local.contributor.authoruidBanwell, Martin, u9500594
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor030401 - Biologically Active Molecules
local.identifier.ariespublicationu4005981xPUB317
local.identifier.citationvolume6
local.identifier.doi10.1002/cbdv.200800319
local.identifier.scopusID2-s2.0-67649369572
local.type.statusPublished Version

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