The influence of platelet membranes on tumour cell behaviour

Date

2017

Authors

Coupland, Lucy
Hindmarsh, Elizabeth
Gardiner, Elizabeth
Parish, Christopher

Journal Title

Journal ISSN

Volume Title

Publisher

Kluwer Academic Publishers

Abstract

The significant role of platelets in the protection of tumour cells from immune attack and shear forces and the promotion of tumour cell extravasation from the bloodstream in the process of haematogenous metastasis have been extensively studied. The role of platelets, and in particular platelet membranes, in the promotion of a more metastatic phenotype in tumour cells is a more recent and, therefore, less well-recognised area of research. This review article summarises studies that have focused on the impact of tumour cell interactions with platelets and platelet membranes on tumour cell behaviour in vitro and in vivo. Furthermore, the gene expression changes that occur within tumour cells following contact with platelet membranes are also extensively reviewed. Overall, the interaction of platelet membranes with tumour cells results in a more invasive phenotype and the promotion of epithelial to mesenchymal transition with our own genetic studies revealing that matrix metalloproteinase-1, plasminogen activator inhibitor-1 and interleukin-8 are globally upregulated in a range of tumour cell lines.

Description

Keywords

Platelets, Platelet membranes, Tumour, EMT, Invasion, Migration

Citation

Source

Cancer and Metastasis Reviews

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

Restricted until

2099-12-31