A pilot study for control of hyperendemic Cystic hydatid disease in China
dc.contributor.author | Zhang, Wenbao | |
dc.contributor.author | Zhang, Zhuangzhi | |
dc.contributor.author | Yimit, Turhong | |
dc.contributor.author | Shi, Baoxin | |
dc.contributor.author | Aili, Hasyeti | |
dc.contributor.author | Tulson, Gulnor | |
dc.contributor.author | You, Hong | |
dc.contributor.author | Li, Jun | |
dc.contributor.author | Gray, Darren J. | |
dc.contributor.author | McManus, Donald P. | |
dc.contributor.author | Wang, Jincheng | |
dc.date.accessioned | 2015-11-01T22:56:13Z | |
dc.date.available | 2015-11-01T22:56:13Z | |
dc.date.issued | 2009-10-27 | |
dc.date.updated | 2015-12-10T08:55:44Z | |
dc.description.abstract | BACKGROUND Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. METHODOLOGY/PRINCIPAL FINDINGS A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. CONCLUSIONS/SIGNIFICANCE The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy. | |
dc.description.sponsorship | This work was supported with funds from the China National Key Technological R&D Programme and the Key R&D Programme of Xinjiang Uygur Autonomous Region. | en_AU |
dc.format | 7 pages | |
dc.identifier.issn | 1935-2735 | en_AU |
dc.identifier.uri | http://hdl.handle.net/1885/16186 | |
dc.publisher | Public Library of Science | |
dc.rights | © 2009 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
dc.source | PLoS Neglected Tropical Diseases | |
dc.subject | animals | |
dc.subject | china | |
dc.subject | dog diseases | |
dc.subject | dogs | |
dc.subject | echinococcosis | |
dc.subject | echinococcus granulosus | |
dc.subject | endemic diseases | |
dc.subject | euthanasia, animal | |
dc.subject | humans | |
dc.subject | infection control | |
dc.subject | pilot projects | |
dc.subject | praziquantel | |
dc.subject | sheep | |
dc.subject | sheep diseases | |
dc.title | A pilot study for control of hyperendemic Cystic hydatid disease in China | |
dc.type | Journal article | |
dcterms.dateAccepted | 2009-09-23 | |
local.bibliographicCitation.issue | 10 | en_AU |
local.bibliographicCitation.startpage | e534 | en_AU |
local.contributor.affiliation | Zhang, Wenbao, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | Zhang, Zhuangzhi, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | Yimit, Thurhong, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | Shi, Baoxin, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | Aili, Hasyeti, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | Tulson, Gulnor, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | You, Hong, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.affiliation | Li, Jun, Queensland Institute of Medical Research, Australia | en_AU |
local.contributor.affiliation | Gray, Darren, College of Medicine, Biology and Environment, CMBE Research School of Population Health, Natl Centre for Epidemiology & Population Health, The Australian National University | en_AU |
local.contributor.affiliation | McManus, Donald P, University of Queensland, Australia | en_AU |
local.contributor.affiliation | Wang, Jincheng, Xinjiang Academy of Animal Science, China | en_AU |
local.contributor.authoremail | darren.gray@anu.edu.au | en_AU |
local.contributor.authoruid | u5624503 | en_AU |
local.description.notes | Imported from ARIES | en_AU |
local.identifier.absfor | 111706 | en_AU |
local.identifier.ariespublication | U3488905xPUB734 | en_AU |
local.identifier.citationvolume | 3 | en_AU |
local.identifier.doi | 10.1371/journal.pntd.0000534 | en_AU |
local.identifier.essn | 1935-2735 | en_AU |
local.identifier.scopusID | 2-s2.0-70449475541 | |
local.identifier.uidSubmittedBy | u3488905 | en_AU |
local.publisher.url | https://www.plos.org/ | en_AU |
local.type.status | Published Version | en_AU |
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