A pilot study for control of hyperendemic Cystic hydatid disease in China

dc.contributor.authorZhang, Wenbao
dc.contributor.authorZhang, Zhuangzhi
dc.contributor.authorYimit, Turhong
dc.contributor.authorShi, Baoxin
dc.contributor.authorAili, Hasyeti
dc.contributor.authorTulson, Gulnor
dc.contributor.authorYou, Hong
dc.contributor.authorLi, Jun
dc.contributor.authorGray, Darren J.
dc.contributor.authorMcManus, Donald P.
dc.contributor.authorWang, Jincheng
dc.date.accessioned2015-11-01T22:56:13Z
dc.date.available2015-11-01T22:56:13Z
dc.date.issued2009-10-27
dc.date.updated2015-12-10T08:55:44Z
dc.description.abstractBACKGROUND Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. METHODOLOGY/PRINCIPAL FINDINGS A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. CONCLUSIONS/SIGNIFICANCE The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy.
dc.description.sponsorshipThis work was supported with funds from the China National Key Technological R&D Programme and the Key R&D Programme of Xinjiang Uygur Autonomous Region.en_AU
dc.format7 pages
dc.identifier.issn1935-2735en_AU
dc.identifier.urihttp://hdl.handle.net/1885/16186
dc.publisherPublic Library of Science
dc.rights© 2009 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.sourcePLoS Neglected Tropical Diseases
dc.subjectanimals
dc.subjectchina
dc.subjectdog diseases
dc.subjectdogs
dc.subjectechinococcosis
dc.subjectechinococcus granulosus
dc.subjectendemic diseases
dc.subjecteuthanasia, animal
dc.subjecthumans
dc.subjectinfection control
dc.subjectpilot projects
dc.subjectpraziquantel
dc.subjectsheep
dc.subjectsheep diseases
dc.titleA pilot study for control of hyperendemic Cystic hydatid disease in China
dc.typeJournal article
dcterms.dateAccepted2009-09-23
local.bibliographicCitation.issue10en_AU
local.bibliographicCitation.startpagee534en_AU
local.contributor.affiliationZhang, Wenbao, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationZhang, Zhuangzhi, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationYimit, Thurhong, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationShi, Baoxin, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationAili, Hasyeti, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationTulson, Gulnor, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationYou, Hong, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.affiliationLi, Jun, Queensland Institute of Medical Research, Australiaen_AU
local.contributor.affiliationGray, Darren, College of Medicine, Biology and Environment, CMBE Research School of Population Health, Natl Centre for Epidemiology & Population Health, The Australian National Universityen_AU
local.contributor.affiliationMcManus, Donald P, University of Queensland, Australiaen_AU
local.contributor.affiliationWang, Jincheng, Xinjiang Academy of Animal Science, Chinaen_AU
local.contributor.authoremaildarren.gray@anu.edu.auen_AU
local.contributor.authoruidu5624503en_AU
local.description.notesImported from ARIESen_AU
local.identifier.absfor111706en_AU
local.identifier.ariespublicationU3488905xPUB734en_AU
local.identifier.citationvolume3en_AU
local.identifier.doi10.1371/journal.pntd.0000534en_AU
local.identifier.essn1935-2735en_AU
local.identifier.scopusID2-s2.0-70449475541
local.identifier.uidSubmittedByu3488905en_AU
local.publisher.urlhttps://www.plos.org/en_AU
local.type.statusPublished Versionen_AU

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