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Substrate-promoted formation of a catalytically competent binuclear center and regulation of reactivity in a glycerophosphodiesterase from Enterobacter aerogenes

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Date

2008

Authors

Hadler, Kieran S
Tanifum, Eric A
Yip, Sylvia
Mitic, Natasa
Guddat, Luke
Jackson, Colin
Gahan, Lawrence
Nguyen, Thi Kelly
Carr, Paul D
Ollis, David

Journal Title

Journal ISSN

Volume Title

Publisher

American Chemical Society

Abstract

The glycerophosphodiesterase (GpdQ) from Enterobacter aerogenes is a promiscuous binuclear metallohydrolase that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of

Description

Keywords

Keywords: Binding energy; Binding sites; Biochemistry; Coordination reactions; Crystal structure; Electrolysis; Enzyme activity; Enzymes; Hydrogen; Hydrogen bonds; Hydrolysis; Ions; Laws and legislation; Metal ions; Metals; Network protocols; Nucleophiles; Quantum

Citation

URI

http://hdl.handle.net/1885/52581

Collections

ANU Research Publications

Source

Journal of the American Chemical Society

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1021/ja803346w

Restricted until

2037-12-31

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Description
01_Hadler_Substrate-promoted_formation_2008.pdf (612.88 KB)

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