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A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode

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Date

2013

Authors

Jergic, Slobodan
Horan, Nicholas P
Elshenawy, Mohamed M
Mason, Claire E
Urathamakul, Thitima
Ozawa, Kiyoshi
Robinson, Andrew
Goudsmits, Joris MH
Wang, Yao
Pan, Xuefeng

Journal Title

Journal ISSN

Volume Title

Publisher

Oxford University Press

Abstract

Processive DNA synthesis by the αÉ"θ core of the Escherichia coli Pol III replicase requires it to be bound to the β 2 clamp via a site in the α polymerase subunit. How the É" proofreading exonuclease subunit influences DNA synthesis by α was not p

Description

Keywords

Keywords: enzyme; exonuclease; polymerase III replicase; unclassified drug; article; binding site; controlled study; DNA replication; DNA synthesis; DNA template; in vitro study; mutagenesis; polymerization; priority journal; protein protein interaction; replisome; beta sliding clamp; DNA polymerase III; DNA replication; Escherichia coli; proofreading exonuclease

Citation

URI

http://hdl.handle.net/1885/62001

Collections

ANU Research Publications

Source

EMBO Journal, The

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1038/emboj.2012.347

Restricted until

2037-12-31

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Description
01_Jergic_A_direct_proofreader-clamp_2013.pdf (1.21 MB)

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