A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode

Jergic, Slobodan; Horan, Nicholas P; Elshenawy, Mohamed M; Mason, Claire E; Urathamakul, Thitima; Ozawa, Kiyoshi; Robinson, Andrew; Goudsmits, Joris MH; Wang, Yao; Pan, Xuefeng; Beck, Jennifer; van Oijen, Antoine M; Hamdan, Samir; Dixon, Nicholas Edward; Huber, Thomas

A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode

Date

2013

Authors

Jergic, Slobodan

Horan, Nicholas P

Elshenawy, Mohamed M

Mason, Claire E

Urathamakul, Thitima

Ozawa, Kiyoshi

Robinson, Andrew

Goudsmits, Joris MH

Wang, Yao

Pan, Xuefeng

Publisher

Oxford University Press

Abstract

Processive DNA synthesis by the αÉ"θ core of the Escherichia coli Pol III replicase requires it to be bound to the β 2 clamp via a site in the α polymerase subunit. How the É" proofreading exonuclease subunit influences DNA synthesis by α was not p