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Effect of gating modifier toxins on membrane thickness: Implications for toxin effect on gramicidin and mechanosensitive channels

Date

Authors

Chen, Rong

Chung, Shin-Ho

Publisher

Open Access

Abstract

Various gating modifier toxins partition into membranes and interfere with the gating mechanisms of biological ion channels. For example, GsMTx4 potentiates gramicidin and several bacterial mechanosensitive channels whose gating kinetics are sensitive to

Keywords

Keywords: gramicidin; heteropodatoxin 2; ion channel; MTx4 toxin; toxin; unclassified drug; article; binding affinity; binding site; channel gating; concentration (parameters); drug potentiation; energy transfer; Grammostola spatulata; hydrophilicity; hydrophobicit Gating modifier toxin; Lipid bilayer; Membrane; Molecular dynamics

URI

http://hdl.handle.net/1885/71668

Collections

ANU Research Publications

Source

Toxins

Type

Journal article

Access Statement

Open Access

DOI

10.3390/toxins5020456

Downloads

File

Description

01_Chen_Effect_of_gating_modifier_2013.pdf (4.07 MB)

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