Chemoenzymatic and enantioselective assembly of the (1α,3aβ,6α,7aβ)-octahydro-1,6-methano-1 H -indene framework associated with 2-isocyanoallopupukeanane: validation of a new synthetic strategy and the identification of enantiomeric switching regimes

Abstract

The octahydro-1,6-methano-IH-indene framework associated with the marine sesquiterpenoid 2-iso- cyanoallopupukeanane (1) has been prepared in enantiomerically pure form from the cis-1,2-dihy- drocatechol 8 using DielsAlder cycloaddition, oxa-di-π-methane Show more