Optimization of aqueous SI-ATRP grafting of Poly(Oligo(Ethylene Glycol) Methacrylate) brushes from benzyl chloride macroinitiator surfaces
Date
2015
Authors
Rodda, Andrew E.
Ercole, Francesca
Nisbet, David R.
Forsythe, John S.
Meagher, Laurence
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-VCH Verlag
Abstract
Poly(oligo(ethylene glycol) methacrylate) (pOEGMA) brushes were grafted via surface-initiated atom transfer radical polymerization (SI-ATRP) from a poly(styrene-co-vinylbenzyl chloride) macroinitiator. While bromoisobutyryl initiator groups are most commonly used for this purpose, benzyl chloride initiators may be advantageous for some applications due to superior stability. Water-only graft solutions produced thicker brush coatings with superior low fouling properties (low protein adsorption and cell adhesion) versus mixed water/alcohol solutions. Coatings produced using 475 Da OEGMA (methyl ether terminated) further reduced non-specific interactions compared to 360 Da OEGMA (hydroxyl terminated). Initiator density had minimal effect on low fouling properties.
Description
Keywords
aqueous ATRP, benzyl chloride, macroinitiator, protein fouling, surface initiated ATRP
Citation
Collections
Source
Macromolecular Bioscience
Type
Journal article