Multi-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels

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dc.contributor.authorHilder, Tamsyn
dc.contributor.authorCorry, Ben
dc.contributor.authorChung, Shin-Ho
dc.date.accessioned2015-12-13T22:15:39Z
dc.date.issued2014
dc.date.updated2015-12-11T07:19:16Z
dc.description.abstractThere is clear evidence that the net magnitude of negative charge at the intracellular end of inwardly rectifying potassium channels helps to generate an asymmetry in the magnitude of the current that will pass in each direction. However, a complete understanding of the physical mechanism that links these charges to current rectification has yet to be obtained. Using Brownian dynamics, we compare the conduction mechanism and binding sites in rectifying and non-rectifying channel models. We find that in our models, rectification is a consequence of asymmetry in the hydrophobicity and charge of the pore lining. As a consequence, inward conduction can occur by a multi-ion conduction mechanism. However, outward conduction is restricted, since there are fewer ions at the intracellular entrance and outwardly moving ions must cross the pore on their own. We pose the question as to whether the same mechanism could be at play in inwardly rectifying potassium channels.
dc.identifier.issn0092-0606
dc.identifier.urihttp://hdl.handle.net/1885/70499
dc.publisherKluwer Academic Publishers
dc.sourceJournal of Biological Physics
dc.titleMulti-ion versus single-ion conduction mechanisms can yield current rectification in biological ion channels
dc.typeJournal article
local.bibliographicCitation.issue2
local.bibliographicCitation.lastpage119
local.bibliographicCitation.startpage109
local.contributor.affiliationHilder, Tamsyn, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationCorry, Ben, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChung, Shin-Ho, College of Medicine, Biology and Environment, ANU
local.contributor.authoremailu4594267@anu.edu.au
local.contributor.authoruidHilder, Tamsyn, u4594267
local.contributor.authoruidCorry, Ben, u9719358
local.contributor.authoruidChung, Shin-Ho, u8809509
local.description.embargo2037-12-31
local.description.notesImported from ARIES
local.identifier.absfor029901 - Biological Physics
local.identifier.absfor030799 - Theoretical and Computational Chemistry not elsewhere classified
local.identifier.absseo970106 - Expanding Knowledge in the Biological Sciences
local.identifier.ariespublicationU3488905xPUB2330
local.identifier.citationvolume40
local.identifier.doi10.1007/s10867-013-9338-4
local.identifier.scopusID2-s2.0-84899989448
local.identifier.thomsonID000334432500001
local.identifier.uidSubmittedByU3488905
local.type.statusPublished Version

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