Feedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite
Date
2007
Authors
Lehane, Adele
Marchetti, Rosa
Spry, Christina
Van Schalkwyk, Donelly
Teng, Rongwei
Kirk, Kiaran
Saliba, Kevin
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Volume Title
Publisher
American Society for Biochemistry and Molecular Biology Inc
Abstract
To survive, the human malaria parasite Plasmodium falciparum must acquire pantothenate (vitamin B5) from the external medium. Pantothenol (provitamin B5) inhibits parasite growth by competing with pantothenate for pantothenate kinase, the first enzyme in
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Keywords
Keywords: Alcohols; Biosynthesis; Cell culture; Diseases; Microorganisms; Vitamins; Erythrocyte; Pantothenate; Pantothenate kinase; Pantothenol; Enzyme inhibition; coenzyme A; dexpanthenol; furosemide; pantothenate kinase; article; enzyme synthesis; erythrocyte; ne
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Source
Journal of Biological Chemistry
Type
Journal article
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2037-12-31
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