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Feedback Inhibition of Pantothenate Kinase Regulates Pantothenol Uptake by the Malaria Parasite

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Date

2007

Authors

Lehane, Adele
Marchetti, Rosa
Spry, Christina
Van Schalkwyk, Donelly
Teng, Rongwei
Kirk, Kiaran
Saliba, Kevin

Journal Title

Journal ISSN

Volume Title

Publisher

American Society for Biochemistry and Molecular Biology Inc

Abstract

To survive, the human malaria parasite Plasmodium falciparum must acquire pantothenate (vitamin B5) from the external medium. Pantothenol (provitamin B5) inhibits parasite growth by competing with pantothenate for pantothenate kinase, the first enzyme in

Description

Keywords

Keywords: Alcohols; Biosynthesis; Cell culture; Diseases; Microorganisms; Vitamins; Erythrocyte; Pantothenate; Pantothenate kinase; Pantothenol; Enzyme inhibition; coenzyme A; dexpanthenol; furosemide; pantothenate kinase; article; enzyme synthesis; erythrocyte; ne

Citation

URI

http://hdl.handle.net/1885/32459

Collections

ANU Research Publications

Source

Journal of Biological Chemistry

Type

Journal article

Book Title

Entity type

Access Statement

License Rights

DOI

10.1074/jbc.M704610200

Restricted until

2037-12-31

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Description
01_Lehane_Feedback_Inhibition_of_2007.pdf (606.88 KB)

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