Longitudinal Changes in Fat Mass and the Hippocampus
Date
Authors
Ambikairajah, Ananthan
Tabatabaei-Jafari, Hossein
Walsh, Erin
Hornberger, Michael
Cherbuin, Nicolas
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Objective
This study aimed to investigate cross‐sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes.
Methods
UK Biobank participants (N = 20,395) aged 40 to 70 years (mean follow‐up = 7.66 years), were included and categorized into one of four groups, which represented their baseline fat mass status and trajectory of change by follow‐up assessment: normal weight to overweight/obesity, overweight/obesity to normal weight (ON), normal weight stable (NS), or overweight/obesity stable (OS). Regression models used NS (WC < 80 cm in women and < 94 cm in men; WTHR < 0.85 in women and < 0.90 in men; BMI < 25 kg/m2 in women and men) as the reference group. Hippocampal volumes were automatically segmented using the FMRIB Software Library.
Results
Compared with NS, OS (BMI: B = −62.23 [SE = 16.76]; WC: B = −145.56 [SE = 16.97]; WTHR: B = −101.26 [SE = 19.54]) and ON (BMI: B = −61.1 [SE = 30.3]; WC: B = −93.77 [SE = 24.96]; WTHR: B = −69.92 [SE = 26.22]) had significantly lower hippocampal volumes.
Conclusions
The detrimental effects of overweight/obesity may extend beyond the duration of overweight/obesity itself.
Description
Keywords
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Source
Obesity
Type
Book Title
Entity type
Access Statement
License Rights
Restricted until
2099-12-31