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The islet b-cell: fuel responsive and vulnerable

Date

Authors

Nolan, Christopher

Prentki, Marc

Publisher

Elsevier

Abstract

The pancreatic β-cell senses blood nutrient levels and is modulated by neurohormonal signals so that it secretes insulin according to the need of the organism. Nutrient sensing involves marked metabolic activation, resulting in the production of coupling

Keywords

Keywords: amino acid; fatty acid; glucose; glycerolipid; cell function; detoxification; glucose metabolism; glucose transport; human; insulin release; nonhuman; nutrient supply; pancreas islet beta cell; priority journal; review; Amino Acids; Animals; Energy Metabo

URI

http://hdl.handle.net/1885/33819

Collections

ANU Research Publications

Source

Trends in Endocrinology and Metabolism

Type

Journal article

DOI

10.1016/j.tem.2008.07.006

Restricted until

2037-12-31

Downloads

File

Description

01_Nolan_The_islet_b-cell:_fuel_2008.pdf (675.42 KB)