Cutting edge: Lectin like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor
Date
2005
Authors
Rosen, David B
Bettadapura, Jayaram
Alsharifi, Mohammed
Mathew, Porunelloor A
Warren, Hilary
Lanier, Lewis L
Journal Title
Journal ISSN
Volume Title
Publisher
American Association of Immunologists
Abstract
Increasingly, roles are emerging for C-type lectin receptors in immune regulation. One receptor whose function has remained largely enigmatic is human NKR-P1A (CD161), present on NK cells and subsets of T cells. In this study, we demonstrate that the lectin-like transcript-1 (LLT1) is a physiologic ligand for NKR-P1A. LLT1-containing liposomes bind to NKR-P1A+ cells, and binding is inhibited by anti-NKR-P1A mAb. Additionally, LLT1 activates NFA T-GFP reporter cells expressing CD3ζ NKR-P1A chimeric receptor; reciprocally, reporter cells with a CD3ζ-LLT1 chimeric receptor are stimulated by NKR-P1A. Moreover, LLT1 on target cells can inhibit NK cytotoxicity via interactions with NKR-P1A.
Description
Keywords
Keywords: CD3 antigen; complementary DNA; green fluorescent protein; lectin like transcript 1; lectin receptor; ligand; liposome; recombinant protein; transcription factor NFAT; unclassified drug; animal cell; article; controlled study; human; human cell; immunoreg
Citation
Collections
Source
Journal of Immunology
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
DOI
Restricted until
2037-12-31
Downloads
File
Description